Crocs were designed for sailors. Three friends needed a non-slip, waterproof boat shoe, so they showed up to a Florida boat show in 2002 with 200 pairs and sold out on the spot.

Twenty years later, Balenciaga was selling them for $850, and Post Malone had a signature edition. Nobody who was on that boat could have seen this coming.

What’s in store:

Read Time: 5 minutes

ANTHROPIC

Anthropic has concerns. Several, actually

A senior Anthropic safety researcher has warned that future AI could pose a serious risk to humanity within the next decade.

Evan Hubinger said he believes there is more than a 10% chance advanced AI could “kill all humans”.

He said today’s models are still low risk, but worries future systems could become powerful enough to improve themselves and become harder to control.

His comments followed a post from Jacob Coxon, a former Anthropic and OpenAI researcher, who said both companies were moving too quickly and warned future AI could hack systems, speed up research and gain access to real-world resources.

Anthropic declined to comment on the posts.

Dame Wendy Hall, who advises the UN on AI, said she was “shocked” by the warnings, while also suggesting some of the comments could be linked to publicity around major AI firms.

The debate has also reached the UK government. Darren Jones called for an international treaty to manage the development of highly advanced AI.

Meanwhile, the Financial Times reported that Anthropic withheld its latest model from the UK’s AI Security Institute.

The Cabinet Office said it continues to work with Anthropic and other companies on AI safety.

In brief:

Nobody asked for these odds

Hubinger also said Anthropic still does not have a clear plan for keeping future superintelligent AI aligned with human goals.

Anthropic’s own August safety report said current risks remain low, but admitted it is less confident than before about some future dangers.

Other AI leaders have recently raised similar concerns, while more than 1,300 AI workers have signed a letter calling for international rules to control the pace of frontier AI development.

Anyone else getting tired of hearing this? - MV

Vote for live results + see results and opinions from yesterday at the bottom of the email.

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Number Crunch

Three runners complete a relay. Runner 1 runs 6 miles at 12 mph, Runner 2 runs 4 miles at 8 mph, Runner 3 runs 10 miles at 10 mph. What's the total time?

Find the answer at the bottom of the email!

Watch This

Sometimes the thing everyone doubts is exactly the thing worth backing. This video uses Stan Lee and Spider-Man to explore how stubborn belief in an idea can push you past scepticism, rejection, and the very reasonable urge to give up.

GOOGLE

The human genome has received extensive feedback

Google DeepMind has created an AI-powered “atlas” that predicts the effects of every possible single-letter change in the human genome.

The AlphaGenome Atlas uses DeepMind’s AlphaGenome model to map around nine billion possible DNA mutations.

The aim is to help scientists understand which genetic changes could affect how genes work, contribute to disease or influence biological traits.

Here’s what you should know:

Patch notes: humanity

The atlas is free for non-commercial research and removes the need for scientists to run the AI model themselves.

DeepMind has also added a score that estimates how significant each genetic variant could be.

Researchers say the tool could help investigate rare diseases and make the harder-to-understand 98% of our DNA easier to study.

However, experts stress that its predictions still need experimental testing and shouldn’t be used alone for clinical decisions.

Nine billion possible mutations and none of them fixed my posture. LAME.- MG

Mindstream Picks

Health: Regularly drinking very hot tea or coffee may triple the risk of oesophageal cancer, with researchers advising people to let drinks cool below 65°C before consuming them.

Gaming: Nintendo will release the final two Kirby Air Riders amiibo on November 12, featuring Sword Kirby with Dragoon and Noir Dedede with Hydra.

Movies: The Italian Job could be getting a sequel more than 20 years later, with Bridesmaids director Paul Feig in early talks to helm the Paramount project.

Don’t Miss: Automattic CEO and WordPress co-founder Matt Mullenweg has been placed on paid leave by the company’s board, with CFO Mark Davies stepping in as interim CEO. The leadership shake-up comes as Automattic remains embroiled in an ongoing legal battle with WordPress hosting company WP Engine.

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Yesterday’s Poll

“Which AI breakthrough would be bigger?”

Major medical breakthroughs - 90% ✅

Actually useful humanoid robots - 10%

Your Views:

“But only if they gave real impact for humans. Breakthrough in vitro or on mice are interesting, but don’t regularly turn into drugs or protocols that help humans. Cancer is a good example of this over-reach. Colloquially we speak of cancer as one huge problem, but if you look at it carefully, it’s a bunch of different ones. Types of cancer differ in how they are caused and how they grow. One solution for all of them is unreasonable” - joann

“100% that's where it should be focused!” - parker

“It’s about time there was a proper cure or vaccine once & for all so the Big Pharma won’t be so big!” - jamesa

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